Articles Tagged with: Dennis Potter

Gene Therapy Cleanroom Facility Wins International Award

The Raymond G. Perelman Center for Cellular and Molecular Therapeutics (CCMT) Clinical Vector Core at the Children’s Hospital of Philadelphia (CHOP) was recognized as a model for the future by the International Society for Pharmaceutical Engineering​ (ISPE) in their 2021 Facility of the Year Awards program.

The Clinical Vector Core (CVC), a state-of-the-art cleanroom facility dedicated to manufacturing adeno-associated and lentiviral vectors, provides viral vectors in support of Phase I and Phase II clinical gene therapy trials in compliance with current Good Manufacturing Practices (cGMP), as well as GMP-process comparable vectors in support of pharmacology/ toxicology pre-clinical studies. Ballinger served as architect and engineer for the project.

The judging panel selected CCMT because of its impact on the future of cell and gene therapy facilities, noting its synergy with the hospital, access to cutting edge medicines, effective use of space, and the social and sustainability value it offers Philadelphia and those receiving treatment.

“Working in collaboration with architects and engineers since 2015, we developed a state-of-the-art GMP manufacturing facility that will help support the growing field of gene therapy not only locally, but nationally and internationally,” said Johannes C. M. van der Loo, PhD, director of the Clinical Vector Core at CCMT. Over the past 17 years, the Clinical Vector Core has manufactured close to 150 clinical grade products for 40 different indications. Vectors have been used in 27 clinical trials in 10 countries.

Ballinger Associate Principal Joshua S. Levy, AIA, LEED AP, who served as Project Architect for the CVC, described the space as “a machine that prioritizes the human experience without compromise to the facility’s stringent operational and performance requirements.”

The project, recognized by the jury as a model for the future, did not fall within one of ISPE’s award categories and was therefore recognized with Honorable Mention. Established in 2004, the Facility of the Year Awards program recognizes the best pharmaceutical and biotechnology manufacturing facilities globally and highlights projects that utilize new, innovative technologies to improve the quality of products, reduce the cost of producing high-quality medicines, and demonstrate advances in project delivery. It provides a platform for the pharmaceutical science and manufacturing industry to showcase accomplishments in facility design, construction, and operation, while sharing the development of new applications of technology and cutting-edge approaches.

Read more about the Clinical Vector Core

Ballinger Presents at ISPE Facilities of the Future Conference

Experts from Ballinger, Children’s Hospital of Philadelphia and IPS gave a presentation at the ISPE 2020 Facilities of the Future Conference. Their talk “Manufacturing Cell and Gene Therapies within the Academic Medical Center Environment” explored the road to a fully validated drug development facility and how architecture and engineering can support the translational research continuum from bench to bedside.

Ballinger Principal Dennis Potter, PE, LEED AP joined Johannes van der Loo, PhD of Children’s Hospital of Philadelphia (CHOP) and Anthony Relvas of IPS to share a case study of a new 15,000 SF cGMP facility on CHOP’s West Philadelphia campus. The presentation covered early planning stages through design, construction, commissioning and qualification, with a focus on how a fully integrated team developed a space that is helping to realize the enormous promise of gene transfer therapy to address unmet medical needs.

The mission of the International Society for Pharmaceutical Engineering (ISPE) is to connect pharmaceutical knowledge to deliver manufacturing and supply chain innovation, operational excellence and regulatory insights. Their annual Facilities of the Future Conference, held this year in San Francisco, brings together professionals involved in all facets of the pharmaceutical manufacturing lifecycle.

Ballinger Announces Expanded Firm Leadership

In the spirit of continued firm growth and evolution, Ballinger is proud to expand our leadership. We are delighted to announce seven new Principals and shareholders of the firm.

Since joining Ballinger in 1999, Steve has served in a variety of firm leadership roles including Architectural Studio Leader and Senior Project Designer. He has worked in diverse market sectors and collaboratively led the design of some of the firm’s most prestigious commissions. He is a frequent speaker at industry forums across the country and will continue to advance the firm’s design portfolio in higher education.

Erin joined Ballinger in 2011 and has served as Director of Project Management as well as Senior Project Manager for many of the firm’s most significant healthcare projects.  Erin has been a spokesperson for Ballinger and the healthcare industry in print and on-air forums, and a mentor for women in design. This year she was named to Healthcare Design Magazine’s HCD 10. In her role as Principal, Erin will continue to cultivate the firm’s healthcare practice.

Angie joined Ballinger in 2000 and emerged as a leader within the firm, first as the Structural Group Manager and now as Chief Structural Engineer.  Her focus on technical expertise, interdisciplinary coordination, and quality control has been key to the successful completion of many complex building and renovation projects. In addition to her engineering leadership, Angie will be expanding her role in client engagement across market sectors.

Tom joined Ballinger in 1997 and has served in leadership roles including Architectural Studio Manager and Senior Project Manager. He has guided diverse healthcare clients through complex renovation and expansion initiatives, orchestrating project teams and facilitating creative design solutions. Tom will continue to manage important client relationships while furthering the expansion and evolution of Ballinger’s healthcare portfolio.

Since joining Ballinger in 1996, Dennis has become a leader in sustainable systems design, applying his expertise to the corporate, academic and healthcare sectors.  Having served as Director of Engineering, he has cultivated the skills of junior engineers, promoted cross-disciplinary collaboration, and been a champion of flexible, efficient engineering solutions. As Principal, Dennis will be expanding the firm’s engineering portfolio across market sectors.

David joined Ballinger in 2019 as Principal after 20 years with KieranTimberlake, where he led many award-winning projects at colleges and universities across the country. He has been published widely, is a frequent lecturer, and has been a juror for multiple award programs. David will concentrate his efforts in the firm’s higher education sector with particular emphasis on client relationship and design management.

Rob joined Ballinger in 1996 and as Associate Principal and Studio Leader has provided leadership through innovation in design and project delivery for some of the firm’s most prestigious academic commissions. His approach to design balances aesthetics and functionality with local context to create enduring solutions. Recognized by clients as a collaborative and engaging leader, Rob will be continuing to advance and expand the firm’s higher education practice.

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UMMC Shock Trauma Achieves LEED Gold

The Shock Trauma Critical Tower at the University of Maryland Medical Center was awarded LEED Gold by the United States Green Building Council (USGBC).

Ballinger provided planning, architecture, engineering and interior design services for this expansion of the University of Maryland Medical Center. The project increases capacity for the R. Adams Cowley Shock Trauma Center, and the adjacent emergency and general surgery departments.

The design incorporates sustainable building materials, a high performance envelope and energy efficient building systems that benefit not just this building but the campus as a whole.  Specific strategies include:

  • 100% storm water reclaimed for use in chillers and landscape irrigation
  • Wind turbines for local sourced green power
  • Building materials with 30% recycled content